Researcher PhD, University of Murcia, Spain
Dr. Rut Valdor Alonso is a distinguished biomedical scientist and Ramón y Cajal (R3-accredited) Researcher at the University of Murcia, Spain. Her pioneering work focuses on chaperone-mediated autophagy (CMA) and its implications in glioblastoma progression, pericyte biology, and immune modulation. With over 17 high-impact publications, three patents, and significant leadership roles in international research networks, she stands as a leading voice in translational cancer research and molecular immunology. Her work continues to influence the future of advanced therapies in neuro-oncology and regenerative medicine.
Professional Profile
Scopus Profile
ORCID
Education
Dr. Valdor earned her Ph.D. in Biology from the University of Murcia in 2008, with a strong focus on cellular and molecular biology. Following her doctoral training, she received the prestigious Seneca Foundation fellowship and began her postdoctoral work at the Virgen de la Arrixaca Hospital’s Experimental Surgery Unit. She then joined the Albert Einstein College of Medicine in New York (2009–2014) as a postdoctoral fellow through an NIH-funded program, where she investigated the role of CMA in aging and T-cell activation. These experiences laid the foundation for her interdisciplinary approach to immune regulation and cancer biology.
Experience
Throughout her career, Dr. Valdor has held pivotal research positions across respected institutions in Spain and the United States. She started her postdoctoral career in Spain at the Fundación para la Formación e Investigación Sanitarias (FFIS) and later at the Department of Anatomy and Psychobiology at the University of Murcia. From 2017 to 2020, she served as a Principal Investigator (PI) under the competitive JIN-MINECO program, where she directed studies on pericytes and immune function in glioblastoma. In 2021, she was awarded the Ramón y Cajal fellowship, a highly competitive national program, which enabled her to launch a dedicated line of research on therapeutic modulation of CMA at the University of Murcia. In addition to her research, Dr. Valdor is an active academic mentor, having supervised numerous postdoctoral fellows, doctoral candidates, and undergraduate students, playing a crucial role in shaping the next generation of scientists.
Research Focus
Dr. Valdor’s research centers on unraveling the cellular mechanisms that govern immune responses, tumor progression, and tissue repair, with particular emphasis on chaperone-mediated autophagy (CMA). She has uncovered how glioblastoma hijacks CMA in pericytes to promote immune suppression, paving the way for novel therapeutic interventions. Her research has led to the development of genetically modified pericytes as potential anti-tumoral agents and is backed by several national and European-funded projects. Dr. Valdor’s cutting-edge work offers promising avenues for treating aggressive brain tumors and chronic inflammatory conditions through modulation of CMA pathways.
Awards & Honors
Dr. Valdor’s outstanding achievements have been widely recognized through numerous national and international awards and fellowships. Early in her career, she was honored with the Keystone Symposium Postdoctoral Award in British Columbia and the Daniel Shields Travel Award at Albert Einstein College of Medicine. Her excellence continued with a postdoctoral fellowship from the NIH and further funding through the Seneca Foundation. She received the MINECO-JIN fellowship to lead her own research group and was later selected for the prestigious Ramón y Cajal program, a testament to her leadership in Spanish biomedical research. Her presentations have received accolades, including Best Communication Prizes at the IMIB-Arrixaca Research Conferences in both 2018 and 2019. In addition to academic distinctions, she has also received support from Fundación La Caixa and Fundación Seneca to advance her translational research. Her appointment in 2025 as a “Profesor Titular” (ANECA-accredited) and her election as Co-Chair of the Women in Autophagy (WIA) Scientific Committee further reflect her professional excellence and commitment to promoting gender equity in science.
Publication Top Notes
Expression of Lumican and Osteopontin in Perivascular Areas of the Glioblastoma Peritumoral Niche and Its Value for Prognosis
Journal: International Journal of Molecular Sciences
Authors: María Dolores Salinas, Pablo Rodriguez, Gonzalo Rubio, Rut Valdor
Summary: This study investigates the expression patterns of Lumican and Osteopontin, two extracellular matrix proteins, within perivascular areas of the glioblastoma peritumoral niche. The research reveals that high expression levels of these proteins correlate with specific prognostic outcomes, potentially serving as biomarkers for tumor aggressiveness. Dr. Valdor contributed to the molecular characterization and immunohistological analysis, offering insights into the tumor microenvironment’s role in glioblastoma progression and recurrence.
The Role of Chaperone-Mediated Autophagy in Tissue Homeostasis and Disease Pathogenesis
Journal: Biomedicines
Authors: Rut Valdor, Marta Martinez-Vicente
Summary: This comprehensive review discusses the pivotal role of chaperone-mediated autophagy (CMA) in maintaining tissue homeostasis and regulating pathological processes, particularly in neurodegenerative diseases, cancer, and immune dysfunctions. Dr. Valdor elaborates on how dysregulation of CMA contributes to disease mechanisms and highlights its therapeutic potential as a targetable pathway. The article integrates findings across multiple models to emphasize CMA’s physiological relevance.
Pericytes, a Cell Type Contributing to Autoimmunity and Immune Tolerance
Book Chapter: Translational Neuroimmunology, Volume 7
Authors: Maria Botía-Sánchez, Maria Luisa Molina, Pedro Aparicio, Rut Valdor
Summary: This chapter provides an in-depth examination of pericytes as immunomodulatory cells involved in the regulation of both autoimmunity and immune tolerance. The authors detail how pericytes influence immune cell trafficking, cytokine release, and local immune responses in the central nervous system. Dr. Valdor contributes her expertise on chaperone-mediated autophagy in pericytes, emphasizing its relevance in neuroinflammation and autoimmunity. The chapter positions pericytes as a promising cellular target for immune-based therapies.
Chaperone-Mediated Autophagy in Pericytes: A Key Target for the Development of New Treatments against Glioblastoma Progression
Journal: International Journal of Molecular Sciences
Authors: María Dolores Salinas, Rut Valdor
Summary: This article identifies chaperone-mediated autophagy (CMA) in pericytes as a critical factor in glioblastoma development. The study demonstrates that modulating CMA alters the immunosuppressive behavior of pericytes within the tumor microenvironment. Targeting CMA can enhance the anti-tumoral functions of pericytes, suggesting a novel therapeutic avenue for glioblastoma treatment. Dr. Valdor served as corresponding author, underscoring her leadership in the field.
Chaperone-Mediated Autophagy Ablation in Pericytes Reveals New Glioblastoma Prognostic Markers and Efficient Treatment Against Tumor Progression
Journal: Frontiers in Cell and Developmental Biology
Authors: Molina ML, García-Bernal D, Salinas MD, Rubio G, Aparicio P, Moraleda JM, Martínez S, Valdor R
Summary: This experimental study provides compelling evidence that genetic ablation of CMA in pericytes significantly impairs glioblastoma progression. The absence of CMA not only reduces tumor-supportive functions but also unmasks prognostic biomarkers linked to patient outcomes. The findings support the development of CMA-targeted peptide therapies, and Dr. Valdor’s contribution as senior researcher and co-author reflects her active role in designing and interpreting the study’s therapeutic implications.
Conclusion
Dr. Rut Valdor Alonso is an innovative and dynamic researcher whose work at the intersection of autophagy, immunology, and cancer therapy holds significant promise for the future of personalized medicine. Through her trailblazing research on pericytes and glioblastoma, her international collaborations, and her mentorship of emerging scientists, she has made substantial contributions to both science and society. Her remarkable achievements make her an exemplary nominee for this prestigious award.